子癇前期患者胎盤組織及血清中TGF-β1的表達及臨床意義.pdf

1、分類號：714.256密級：非密UDCUDC：610學校代碼：11065碩士學位論文子癇前期患者胎盤組織及血清中子癇前期患者胎盤組織及血清中TGFTGFβ1的表達及臨床意義的表達及臨床意義史翠霞指導教師齊衛紅副主任醫師學科專業名稱婦產科學論文提交日期2016年4月12日論文答辯日期2016年5月27日答辯委員會主席楊興升教授AbstractObjectiveAnalysisoftransfminggrowthfact1(TGF1)inp

2、atientswithpreeclampsiaplacentaexpressionclinicalsignificanceofplasma.MethodFebruary2013toFebruary2014periodinaffiliatedhospitalofQingdaoUniversityinthetreatmentof48patientswithpreeclampsiastudymildpreeclampsia25casessev

3、erepreeclampsiain23casesexcludethecomplicationcomplication.Romly34casesofnmalpregnantwomeninthecontrolgroupruleoutcomplicationsothercomplications.TakenonthreeteamsofpregnantwomenserumlevelsofTGF1detectionlocalizationexpr

4、essionofTGF1inplacentatissueproteinanalysis.Bydoubleantibodyswichenzymelinkedimmunosbentassay(ELISA)fdeterminationofserumexpressionofTGF1in.MarkusingWesternblothybridizationTGFβprotein1expressioninplacenta.Whileinpatient

5、swithpreeclampsiaplacentaserumlevelsofTGF1lowcrelationwiththeonsetseverityofpreeclampsiawereanalyzed.Results1.ObservationgroupinthemildseverepreeclampsiaplacentatissueexpressionofTGF1washigherthanthatinthecontrolgroupP=0

6、.008(P0.01)therearesignificantdifferences.2.GroupweightplasmalevelsofTGF1inseverepreeclampsiawerehigherthanthoseinthecontrolgroupcomparedifferencesP=0.02(P0.05)withstatisticalsignificance.3.Agroupofseverepreeclampsiaplac

7、entaexpressionofTGF1inplasmathanmildpreeclampsiagroupP0.05wasstatisticallysignificant.4.InplacentatissueofpatientswithpreeclampsiaTGFbeta1expressionwerepositivelycrelatedwithserumlevelsofTGFbeta1（r=0.789，t＝3.021，P＜0.01）.

8、Conclusion1.TGF1isinvolvedintheoccurrencedevelopmentofpreeclampsiamainlyproducesactsontheplacentareleasedintotheplasma.2.thepatientsillnesshasaverycloserelationshippositivelycrelated.3.Inpreeclampsiainpregnantwomenplasma